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By E. Poisson

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Extra info for A Relativist's Toolkit - The Math of Black Hole Mechanics

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Kinesin-1 is a multifunctional cargo transporter in cells, carrying neuronal vesicles, mitochondria, peroxisomes, and RNA, among other cargoes. Roughly 90% of kinesin in cells is not bound to microtubules or actively transporting cargo, but rather is inactive in the cytoplasm [28,29]. In this inactive state, kinesin-1 bends at a hinge in the middle of the molecule to produce a “folded over” conformation in which the N-terminal enzymatic motor heads and the C-terminal tails interact directly [30–32].

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Xiao, T. et al . (2008) Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces. Molecular Cell , 32, 849–861. [25] Harjanto, D. H. (2010) Matrix mechanics and receptor–ligand interactions in cell adhesion. Organic & Biomolecular Chemistry, 8, 299–304. , Elad, N. et al . (2010) Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography. Nature Cell Biology, 12, 909–915. M. (2002) Cell interactions with three-dimensional matrices.

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