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By Paul H. Sugarbaker MD, FACS, FRCS (auth.), Santiago González-Moreno MD, PhD (eds.)

S. González-Moreno (Ed. ) Advances in Peritoneal floor Oncology With forty five Figures in fifty seven Separate Illustrations, 12 in colour and 19 Tables 123 IV Preface Santiago González-Moreno, MD, PhD division of Surgical Oncology Centro Oncológico MD Anderson overseas España Calle Gómez Hemans 2 28033 Madrid Spain sgonzalez@mdanderson. es Library of Congress keep watch over quantity: 2006937141 ISSN 0080-0015 ISBN 978-3-540-30759-4 Springer Berlin Heidelberg long island This paintings is topic to copyright. All rights are reserved, even if the complete or a part of the fabric is anxious, speci? ?cally the rights of translation, reprinting, reuse of illustrations, recitations, broadcasting, replica on micro? ?lm or in the other approach, and garage in info banks. Duplication of this e-book or elements thereof is allowed in simple terms lower than the provisions of the German Copyright legislations of September nine, 1965, in its present model, and permission to be used should always be bought from Springer-Verlag. Violations are chargeable for prosecution below the German Copyright legislations. Springer is a part of Springer Science+Business Media http//www. springer. com Springer-Verlag Berlin Heidelberg 2007 revealed in Germany using normal descriptive names, emblems, and so on. during this booklet doesn't mean, even within the absence of a speci? ?c sta- ment, that such names are exempt from the proper protecting legislation and laws and for that reason loose for common use. Product legal responsibility: The publishers can't warrantly the accuracy of any information regarding dosage and alertness contained during this booklet. In each case the consumer needs to cost such info through consulting the appropriate literature.

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Furthermore, neutralizing antibody for integrin α1, α2, and β1 subunits can inhibit the adhesion of cancer cells to the peritoneum. These results suggest integrins as target molecules to consider in research for the prevention of peritoneal dissemination. Furthermore, complementary DNA microarray and histochemical analyses revealed differences in the concerted expressions of several genes coding for matrix proteinases, cell adhesion, motility, angiogenesis, and proliferation between the highly metastatic and parental cell lines [27].

This is one of the prime reasons behind our recommendation that the serosal surface should never be painted at the time of macroscopic assessment (Fig. 3) [14]. It does seem that, in the UK at least, pathologists are fast becoming masters of the canvas, with every specimen being liberally covered with paints of many differing colours (often to the detriment of the accurate identification of key pathological features). We think that such a practice should be vociferously discouraged. Only the true surgical margin (whether in the oesophagus, stomach, colon or rectum) should be painted and all serosal surfaces should be left uncoloured.

Although mucinous tumours of the appendix bear some morphological resemblance to mucinous ovarian tumours of borderline malignant potential, these lesions cannot be considered in a similar manner, as appendiceal lesions will carry a much less favourable prognosis [45]. The following classification of mucinous appendiceal tumours has been suggested to accommodate morphological and prognostic implications [45]: ● Low-grade appendiceal mucinous neoplasm (LAMN) (Fig. 6) ● Mucinous adenocarcinoma (MACA) (Fig.

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